Progesterone for preterm labour

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The changing role of progesterone in preterm labour.

Progesterone is an essential hormone in the process of reproduction. It is involved in the menstrual cycle, implantation and is essential for pregnancy maintenance. Although the pharmacokinetics and pharmacodynamics of progesterone have been well studied, and since 1935 it has been synthesised and is now available commercially, its use in the pathophysiology of pregnancy remains controversial. ...

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Increased saliva oestriol to progesterone ratio before idiopathic preterm delivery : a possible predictor for preterm labour ?

Saliva oestriol, oestradiol, and progesterone concentrations were measured in 23 women who went into spontaneous preterm labour. The patients fell clinically and biochemically into two groups. The 13 who went into preterm labour with intact membranes had a saliva oestriol to progesterone ratio greater than one in every case and greater than the 95th centile for their length of gestation in 12 c...

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Trial protocol OPPTIMUM– Does progesterone prophylaxis for the prevention of preterm labour improve outcome?

BACKGROUND Preterm birth is a global problem, with a prevalence of 8 to 12% depending on location. Several large trials and systematic reviews have shown progestogens to be effective in preventing or delaying preterm birth in selected high risk women with a singleton pregnancy (including those with a short cervix or previous preterm birth). Although an improvement in short term neonatal outcome...

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Management of preterm labour.

The above quote testifies to the complexity of preterm labour, a process that ultimately results in considerable neonatal morbidity and mortality. It is diYcult to quantify the incidence of spontaneous preterm labour, as many studies relating to preterm birth do not discriminate between spontaneous preterm labour and iatrogenic/therapeutic preterm delivery. The picture is further complicated as...

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Pathophysiology of preterm labour.

A specific pathogenic process of premature delivery represents the inflammation. Birth canal infections seem to play a key role in the ethiopathogenesis of premature delivery; the related biochemical changes significantly affect perinatal morbidity and mortality. Other potential causes, particularly hormone metabolism disorders or uteroplacental ischaemia have been intensively studied. This pro...

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ژورنال

عنوان ژورنال: BJOG: An International Journal of Obstetrics & Gynaecology

سال: 2016

ISSN: 1470-0328

DOI: 10.1111/1471-0528.13976